Objective To investigate the diagnostic value of serum microRNA-432 (miR-432),vascular endothelial growth factor (VEGF) and carbohydrate antigen 125 (CA125) combined detection in patients with pulmonary tuberculosis. Methods A total of 70 patients with pulmonary tuberculosis admitted to Luohe infectious disease hospital from April 2021 to June 2023 were selected as the study group,and 70 healthy people during the same period were selected as the control group.Patients were divided into active stage pulmonary tuberculosis and latent stage pulmonary tuberculosis group according to the clinical symptoms.MiR-432,VEGF,CA125,C-reactive protein (CRP) and tumor necrosis factor-A (TNF-a) were compared between the two groups on admission,and their correlation was analyzed.Serum indexes level of patients with different stage were compared on admission,and the diagnostic value of combined detection of all indexes on admission was analyzed. Results The levels of miR-432,VEGF,CA125,CRP and TNF-a in the study group were higher than those in the control group (P<0.05).MiR-432,VEGF and CA125 were positively correlated with CRP and TNF-a in the study group on admission (P<0.05).The levels of miR-432,VEGF and CA125 in patients with active pulmonary tuberculosis were higher than those with latent pulmonary tuberculosis infection (P<0.05).The area under the curve (AUC) of serum miR-432,VEGF and CA125 combined detection was 0.937 on admission. Conclusion The combined detection of serum miR-432,VEGF and CA125 can improve the diagnostic efficiency of pulmonary tuberculosis and play an auxiliary role in clinical diagnosis.
Key words
MiR-432 /
VEGF /
CA125 /
Tuberculosis
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