Objective To explore hepatitis B virus (HBV) infection status and its influencing factors among people in Xiamen City,and provide guidance for the formulation of prevention and control measures. Methods A multi-stage stratified sampling method was applied to select 489 participants in 15 age groups from 6 neighborhood committees (villages) in 2 districts of Xiamen City in 2021.A questionnaire survey was conducted and blood samples were collected to test for 5 indicators of HBV infection.The HBV infection rate and other indicators were calculated,and logistic regression analysis was used to identify the influencing factors of HBV infection. Results A total of 489 participants were investigated,and 265 of them were female,accounting for 54.19%;age range was mainly 0-5,with 190 participants,accounting for 38.85%;the marital status was mainly unmarried,with 365 participants,accounting for 74.64%;the main occupation was students,with 147 participants,accounting for 30.06%;388 participants (79.35%) received ≥ 3 doses of hepatitis B vaccine.Among 489 survey subjects,115 were HBV infected,with an HBV infection rate of 23.52% and a standardized rate of 40.37%.The logistic regression analysis results showed that farmers (OR=7.301,95%CI:1.018-52.342),6-10 years old (OR=10.859,95%CI:1.012-116.578),11-20 years old (OR=9.583,95%CI:1.138-80.682),21-50 years old (OR=7.214,95% CI: 1.016-51.213),and ≥ 51 years old (OR=11.752,95%CI:2.342-58.973) were risk factors for HBV infection;≥ 3 doses hepatitis B vaccine (OR=0.137,95%CI:0.021-0.892) was the protective factor of HBV infection. Conclusions The hepatitis B prevention and control efforts in Xiamen City have shown certain effectiveness,but there is still room for improvement.