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Analysis of norovirus surveillance results for patients with foodborne diseases in Anhui Province from 2021 to 2023
FAN yong, ZHANG Zhuhui, LI Shanshan, XU Lizi, MENG Can, WANG Zhiqiang, LI Weidong
Anhui Journal of Preventive Medicine ›› 2025, Vol. 31 ›› Issue (3) : 187-190.
PDF(1154 KB)
PDF(1154 KB)
Analysis of norovirus surveillance results for patients with foodborne diseases in Anhui Province from 2021 to 2023
Objective To analyze the monitoring results of norovirus infection in foodborne patients in Anhui Province from 2021 to 2023,and provide evidence for the prevention and health education of foodborne diseases caused by norovirus infection. Methods The case information of the patients whose specimens were collected and reported by the active monitoring hospitals in the foodborne disease surveillance system of Anhui Province from January 2021 to December 2023.Norovirus-positive rates for foodborne illness cases were calculated and SPSSPRO was used for statistical analysis. Results A total of 9 903 cases of foodborne diseases were reported,of which 1 131 were positive,and the norovirus positive rate was 11.42%.G Ⅰ,G Ⅱ,and uncategorized norovirus accounted for 13.79%,66.05%,and 20.16% of norovirus positive cases,respectively.From 2021 to 2023,there was a statistically significant difference (
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| [2] |
With the improvements of sanitation and nationwide safe water supply the occurrence of bacterial diarrhea declined remarkably, while viruses became the leading causes of acute gastroenteritis (AGE). Of these viruses, noroviruses (NoVs) are responsible for a considerable burden of gastroenteritis, especially in children < 2 years and elderly ⩾ 65 years. NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being the dominant strain followed by GII.3. Given the widespread contamination in environmental sources, and highly infectious nature of NoVs, vaccination would be the desirable strategy for the control of NoV infections. However, a better understanding of acquired immunity after infection, and a reliable immunological surrogate marker are urgently needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical evaluations in China.
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| [3] |
Norovirus (NoV) is an enteric non-enveloped virus which is the leading cause of gastroenteritis across all age groups. It is responsible for around 200,000 deaths annually and outbreaks are common in small communities such as educational and care facilities. 40% of all NoV outbreaks occur in long-term and acute-care facilities, forming the majority of outbreaks. Nosocomial settings set ideal environments for ease of transmission, especially due to the presence of immunocompromised groups. It is estimated to cost global economies around £48 billion a year, making it a global issue. NoV is transmitted via the faecal-oral route and infection with it results in asymptomatic cases or gastrointestinal disease. It has high mutational rates and this allows for new variants to emerge and be more resistant. The classification system available divides NoV into 10 genogroups and 49 genotypes based on whole amino acid sequencing of VP1 capsid protein and partial sequencing of RdRp, respectively. The most predominant genotypes which cause gastroenteritis in humans include GI.1 and GII.4, where GII.4 is responsible for more extreme clinical implications such as hospitalisation. In addition, GII.4 has been responsible for 6 pandemic strains, the last of which is the GII.4 Sydney (2012) variant. In recent years, the successful cultivation of HuNoV was reported in stem cell-derived human intestinal enteroids (HIEs), which promises to assist in giving a deeper understanding of its underlying mechanisms of infection and the development of more personalized control measures. There are no specific control measures against NoV, therefore common practices are used against it such as hand washing. No vaccine is available, but the HIL-214 candidate passed clinical phase 2b and shows promise.
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| [4] |
Human noroviruses are recognised as the major global cause of viral gastroenteritis. Here, we provide an overview of notable advances in norovirus research and provide a short recap of the novel model systems to which much of the recent progress is owed. Significant advances include an updated classification system, the description of alternative virus-like protein morphologies and capsid dynamics, and the further elucidation of the functions and roles of various viral proteins. Important milestones include new insights into cell tropism, host and microbial attachment factors and receptors, interactions with the cellular translational apparatus, and viral egress from cells. Noroviruses have been detected in previously unrecognised hosts and detection itself is facilitated by improved analytical techniques. New potential transmission routes and/or viral reservoirs have been proposed. Recent in vivo and in vitro findings have added to the understanding of host immunity in response to norovirus infection, and vaccine development has progressed to preclinical and even clinical trial testing. Ongoing development of therapeutics includes promising direct-acting small molecules and host-factor drugs.
|
| [5] |
|
| [6] |
WangLP,
National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features of the 152,792 eligible patients enrolled in this analysis. Rotavirus A and norovirus are the two leading viral pathogens detected in the patients, followed by adenovirus and astrovirus. Diarrheagenic Escherichia coli and nontyphoidal Salmonella are the two leading bacterial pathogens, followed by Shigella and Vibrio parahaemolyticus. Patients aged <5 years had higher overall positive rate of viral pathogens, while bacterial pathogens were more common in patients aged 18‒45 years. A joinpoint analysis revealed the age-specific positivity rate and how this varied for individual pathogens. Our findings fill crucial gaps of how the distributions of enteropathogens change across China in patients with diarrhea. This allows enhanced identification of the predominant diarrheal pathogen candidates for diagnosis in clinical practice and more targeted application of prevention and control measures.
|
| [7] |
樊勇, 徐粒子, 孟灿, 等. 2017—2021年安徽省食源性腹泻病例病原学分析[J]. 中国食品卫生杂志, 2024, 36(1):88-92.
|
| [8] |
陆冬磊, 段胜钢, 齐辰, 等. 2014—2018年上海市食源性疾病病例流行特征及饮食史分析[J]. 现代预防医学, 2020, 47(11):1970-1974.
|
| [9] |
翟前前, 张新刚, 刘思洁. 2016—2020年吉林省食源性疾病流行病学特征分析[J]. 现代预防医学, 2022, 49(6):1133-1136.
|
| [10] |
贺悦, 齐小娟, 王绩凯, 等. 浙江省2021年食源性疾病监测结果分析[J]. 中国卫生检验杂志, 2023, 33(4):504-508.
|
| [11] |
汤巧雨, 高玺玉, 宋杨, 等. 2007—2021 年我国诺如病毒急性胃肠炎暴发疫情流行特征及影响因素分析[J]. 中华流行病学杂志, 2023, 44(5):751-758.
|
| [12] |
郭黎, 蔡伟, 邵云平. 2019—2020年北京市海淀区中小学校食堂厨工诺如病毒隐性感染和聚集性疫情分析[J]. 疾病监测, 2022, 37(3):352-355.
|
| [13] |
刘白薇, 高志勇, 贾蕾, 等. 北京市2014—2018年诺如病毒急性胃肠炎暴发的影响因素分析[J]. 中华流行病学杂志, 2019, 40(10):1274-1278.
|
| [14] |
徐粒子, 樊勇, 李卫东. 安徽省2020年新冠肺炎疫情防控期间食源性疾病暴发事件流行病学分析[J]. 安徽预防医学杂志, 2023, 29(1):56-60.
|
| [15] |
杨丽, 段德水, 孙婷, 等. 2014—2016年济南市哨点医院食源性诺如病毒感染病例流行病学特征分析[J]. 中国食品卫生杂志, 2018, 30(3):264-269.
|
| [16] |
Noroviruses are genetically diverse RNA viruses associated with acute gastroenteritis in mammalian hosts. Phylogenetically, they can be segregated into different genogroups as well as P (polymerase)-groups and further into genotypes and P-types based on amino acid diversity of the complete VP1 gene and nucleotide diversity of the RNA-dependent RNA polymerase (RdRp) region of ORF1, respectively. In recent years, several new noroviruses have been reported that warrant an update of the existing classification scheme. Using previously described 2× standard deviation (sd) criteria to group sequences into separate clusters, we expanded the number of genogroups to 10 (GI-GX) and the number of genotypes to 49 (9 GI, 27 GII, 3 GIII, 2 GIV, 2 GV, 2 GVI and 1 genotype each for GVII, GVIII, GIX [formerly GII.15] and GX). Viruses for which currently only one sequence is available in public databases were classified into tentative new genogroups (GNA1 and GNA2) and genotypes (GII.NA1, GII.NA2 and GIV.NA1) with their definitive assignment awaiting additional related sequences. Based on nucleotide diversity in the RdRp region, noroviruses can be divided into 60 P-types (14 GI, 37 GII, 2 GIII, 1 GIV, 2 GV, 2 GVI, 1 GVII and 1 GX), 2 tentative P-groups and 14 tentative P-types. Future classification and nomenclature updates will be based on complete genome sequences and will be coordinated and disseminated by the international norovirus classification-working group.
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| [17] |
|
| [18] |
HallAJ,
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