Objective To understand the characteristics of Clonorchis sinensis infection in Pengjiang District of Jiangmen City,Guangdong Province,and to provide basis for prevention and control strategy. Methods From November to December 2021,the feces of residents over 3 years old from 5 administrative villages (communities) in Pengjiang District were collected,and the eggs of Clonorchis sinensis were detected and counted by modified Kato thick smear method. Results A total of 964 people were examined in 5 administrative villages in Pengjiang District,159 were positive,and the infection rate was 16.49% (159/964).The highest infection rate was 41.26% (85/206) in Dalin Village,Tangxia Town,and there was significant difference among all administrative villages (χ²=134.530,P<0.001).The infection rate of males was 26.53%(130/490) higher than that of females 6.12%(29/474),and the difference was statistically significant (χ²=71.412,P<0.001).For different age groups,the infection rate was highest in the 50-59 age group,at 28.10%(43/153),and there was significant difference among different groups (χ²=65.780,P<0.001).The infection rate in different occupations,farmers was highest at 47.90% (57/119),and there was significant difference among different groups (χ²=127.910,P<0.001).The infection rate among junior high school students was 25.42% (75/295),and there was significant difference among different educational levels (χ²=44.954,P<0.001).In terms of infection degree,90.57% (144/159),9.43% (15/159) and 0 were found to be mild,moderate and severe,respectively. Conclusion The infection rate of Clonorchis sinensis is still high in Pengjiang District,and comprehensive control measures should be taken.