Objective To analyze the serotype distribution and antimicrobial resistance of salmonella strains isolated from clinic patients in Hefei from 2013 to 2015, and provide references for the prevention and clinical treatment of salmonella infection. Methods All strains which were isolated from feces of clinic patients were separated and identified according to the guide of food-borne disease surveillance, and then positive strains were conducted for biochemical tests and antibiotic resistance analysis by automated microbiology analyzer. Results 75 salmonella strains were isolated in 2013~2015. S.Typhimurium and S.Enteritidis count 57.0%(43/75) of all the positive strains. The drug resistance rate was 85.3%(64/75), while multi-drug resistance rate was 24.0%(18/75). S. Enteritidis showed as high as 95.0%(19/20) resistance to nalidixic acid while S.Typhimurium showed 74.0% (17/23)resistance to tetracycline. 22.7%(15/66)strains isolate from children were multi-drug resistance, while no multi-drug resistant strain showed in adult. Conclusion S.Typhimurium and S.Enteritidis were the most frequently isolated salmonella serovars from clinic patients in Hefei, and meanwhile there were other diversity serovars.Though the drug resistance was severe, strains hadn't showed high resistance to clinical commonly used drugs. Precautions should be paid on multi-drug resistance phenomenon of the strains from children.
Key words
Salmonella serotype /
Distribution /
Drug resistance
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 王爱敏,何磊燕,徐学斌,等. 2010年夏季急性细菌感染性腹泻患儿沙门菌感染分析[J]. 微生物与感染,2011,6(3):139-143.
[2] Rice DH, Hancock DD, Roozen PM,et al. Household contamination with salmonella enterica[J]. Emerg Infect Dis,2003,9:120-122.
[3] Nazek Al-Gallas, Mohamed Salah Abbassi, Becher Gharbi,et al. Occurrence of plasmid-mediated quinolone resistance determinants and rmtB gene in salmonella enteric serovar enteritidis and typhimurium isolated from food-animal products in tunisia[J].foodborne pathogens and diease,2013,10(9):1-7.
[4] 倪佳琳,马蓉,胡雪明,等. 159株沙门菌血清学鉴定和耐药性分析[J]. 中国卫生检验杂志,2013,23(4):1012-1014.
[5] 林文娟,刘渠,白江涛,等. 2010-2012年深圳市龙岗区致感染性腹泻沙门菌的流行特征和分子分型[J]. 中国病院生物学杂志,2014,9(6):519-522.
[6] Fedorka-cray PJ,Friedman S,Zhao S,et al. Characterization of salmonella Typhimurium of Animal Origin Obtained from the National Antimicrobial Resistance Monitoring System[J]. Foodborn pathogens and diease 2005,2(2):169-181.
[7] Hakanen AJ,Lindgren M,Huovinen P,et al. New Quinolone Resistance Phenomenon in Salmonella enterica: Nalidixic Acid-Susceptible Isolates with Reduced Fluoroquinolone Susceptibility[J].Journal of clinical microbiology,2005,43(11):5775-5778.
[8] Medalla F,Hoekstra M, Whichard JM,et al. Increase in resistance to ceftriaxone and nonsusceptibility to ciprofloxacin and decrease in multidrug resistance among salmonella strains, United States,1996-2009[J]. Foodborne Pathog Dis,2013,10(4):302-309.
PDF(788 KB)
