Objective To investigate the drug-resistance transmission and subtypes disttcilution in newly diagnosed HIV-1 case population in Hotan prefecture of XinJiang. Methods Random sampling was carried out to choose newly diagnosed HIV-1 infected population from 2013 to 2014. We detected HIV-l pol genotype and genetic mutations associated with drug resistance, and evaluated the level of the transmission HIV-1 drug-resistant strain in newly diagnosed HIV-1 infected population. Results A total of 203 plasma samples were successfully sequenced, with 07_BC were major genetic subtype which accounted for 95.07%, and C subtype were 5 which accounted for 2.46%. HIV-1 POL drug-resistant gene mutation was analyzed, which showed that the incidence of PR was 0.99% and RT was 2.46%. Total transmission rate of HIV-1 resistance was less than <5％. Conclusion 07_BC was the major epidemic genetic genotype. PR and RT drug-resistant HIV-1 strains were found in newly diagnosed HIV-1 population before starting ART in Hotan prefecture of XinJing.The prevalence was low, and surveillance of drug resistance should be carried out timely.
Key words
HIV/AIDS /
Virus subtype /
Drug resistance /
Gene mutation
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