Objective To analyze the epidemic condition of HFMD between 2012 and 2016 in Shitai county,and provide a scientific basis for prevention and control work in the future. Methods Monitoring data on HFMD were collected from the disease surveillance information reporting system. Excel 2007, SPSS20, SaTScan9.3 and ArcGIS10.2 software were used for data analysis. Result From 2012 to 2016, 480 patients with HFMD were reported from Shitai county. The average annual incidence of HFMD was 102.43/105. Most of children were under the age of five. 62.50% of cases were mainly focused on 1-3 year old age group. The scattered living children and childcare children accounted for 94.38% of all cases. Incidence of male was higher than that of female. Peaks were in the turn of the spring and summer, autumn and winter, which accounted for 63.33% of all cases. The area with high incidence mainly concentrated in the east towns between 2012 and 2016. Four HFMD public health emergencies were reported, and all the cluster events occurred in nurseries or kindergartens. The main pathogenic spectrum was Cox-A16, with 42.28% confirmed cases. Space-time clustering analysis showed that the class 1 clustering area was located in our county in eastern and southern regions. Conclusions The incidence of HFMD showed a downward trend, but the pressure still exists. We should take targeted measures to prevent and control the key population and region during high risk time.