Objective To study the occurrence situation of suspected adverse event cases of immunization (AEFI) in Wuhu county and to study the security of conventional and intensification vaccination, so as to provide a scientific basis for immunization planning decisions. Methods AEFI data during the period of 2014-2016 were collected through the AEFI Monthly Routine Report System of Wuhu county and the China Information System for National Immunization Program (NIP). The descriptive methodology was used to conduct epidemiological analyses. Results 74 AEFI cases were reported from 2014 to 2016, there were 60 (81.08%) cases with general reactions and 14 (18.92%) cases with paradoxical reactions. There were 13 kinds of vaccines involved in AEFI cases. The reported incidence of AEFI was 29.80/105, the general reactions incidence was 24.16/105 and the paradise incidence was 5.64/105. The reported and investigated rates within 48h were 94.59% and 100%. 95.95% AEFI cases occurred within 1 day after vaccination. Cases mainly happened in young who were 4 years old or less. The clinical diagnosis of AEFI cases were fever, flare, induration and anaphylaxis. 85.14% of AEFI cases occurred because of the first class vaccinations, these cases included DTaP vaccine (22.97%), MCV-A+C vaccine (16.22%) and MR vaccine (8.11%) and so on. There were statistics significance between the general reactions of NIP vaccination and the second type of vaccine the abnormal reactions were no different. Conclusion The AEFI monitoring system was running in good condition in Wuhu county. It is necessary to strengthen the specification disposal,specify the technological process and operation of vaccination,and pay attention to the publicity and education and risk communication of AEFI.Then we can reduce the occurrence rate of AEFI.