Objective To explore more accurate, more superior, more economical and less risk treatment plan for cesarean scar pregnancy by comparing the clinical effects of different surgical methods. Methods There were 110 cases of cesarean scar pregnancy collected in Anhui women and children health care hospital from January 2013 to April 2016 were selected and treated by transvaginal uterine scar pregnancy resection (operation A), uterine artery embolization plus uterine curettage (operation B) and hysteroscopy plus uterine curettage (operation C). The operation time, bleeding volume, complications, postoperative hospitalization time and hospitalization expenses were taken as the observation indexes. T test or Fisher exact test method was used to analyze the operation time, bleeding volume, complication, postoperative hospital stay and hospitalization cost of these cases. Results Intraoperative bleeding volume of the three operative methods were 103.8 ml, 48.8 ml, 283.3 ml, respectively. Postoperative hospital stay were 7.3 d, 13.0 d, 7.0 d, respectively. Complication occurring rates were 1.7%, 0.0%, 13.3%, respectively. There were significantly different between the three operative methods (P value all<0.05). The operation B had the advantages of less bleeding, low complications, and the disadvantages of the long operation time and hospital stay, and high cost. The other two operative methods had the advantages of short hospital stay and low cost, but had the disadvantages of more intraoperative bleeding and higher complications. Conclusion The three kinds of operation were all effective treatment methods, but each had its own merits and demerits in the amount of bleeding, length of stay, complications and other observational indicators.