Objective To estimate the incidence of congenital syphilis in 2015 in Anhui province. Methods Reported numbers of congenital syphilis in 2015 in Anhui province were collected from the Information System of the National Disease Prevention and Control (DC information system) and the Information System of the Prevention of Maternal to Child Transmission of HIV, Syphilis and Hepatitis B (PMTCT information system).The number of newborns in 2015 was collected from the hospital report.Relevant indicators were collected from the. Results the evaluation of reported congenital syphilis cases in 2015 in Anhui. Results In 2015, the DC information system reported 323 congenital syphilis cases, the PMTCT information system reported 5 cases, and there were 751132 newborns reported by hospitals in Anhui province.Based on the DC information system, the estimated congenital syphilis cases were 128-200, which were 39.3-61.9% of the reported number.The estimated incidence was 17.0/10⁵-26.6/10⁵.Based on the PMTCT information system, the estimated congenital syphilis cases were 99-158,which were 19.8-31.6 of the reported number.The estimated incidence was 13.2/10⁵-21.0/10⁵. Conclusion In 2015 in Anhui province, the estimated incidence rate of congenital syphilis was 13-26/10⁵, using 2 estimation methods.