Objective To understand the contamination level of major pollutants in food in Wenling City and to analyze the contamination situation of different harmful factors in food. Methods During the period of 2014-2017, food samples were collected from supermarkets, vegetable farms, agricultural wholesale markets of agricultural products, restaurants and convenience stores in Wenling urban and township areas in different seasons every year. Heavy metals and microorganisms in food were detected according to the Manual for China National Food Contamination and Harmful Factors Risk Monitoring. Results A total of 1 632 food samples were detected, of which 1 462 were qualified, the qualified rate was 89.58%. 47 indicators of 37 kinds of food were detected. The unqualified indicators were aluminum, sulfur dioxide, Vibrio parahaemolyticus, Vibrio vulnificus, Staphylococcus aureus, Anisakis, Listeria monocytogenes, Salmonella and Vibrio cholerae (non-O1O139). Conclusion The qualified rate of food samples in Wenling City is high, but there are still food safety risks supervision should be strengthened to ensure food safety.