Objective To analyze the epidemic characteristics, prevention and treatment process of malaria in Meizhou City, summarize the prevention and control effect, and cope with new challenges. Methods Data of malaria prevalence and elimination in Meizhou City from 1950 to 2018 were collected to summarize and analyze the epidemic situation of malaria, malaria control measures and effects over the years. Results From 1950 to 2018, 985 224 cases of malaria and 203 malaria death cases were reported in Meizhou City. Malaria prevention and control has gone through four stages, that is the stage of outbreak and control (1950-1959), the stage of epidemic rebound and comprehensive prevention (1960-1979), the stage of monitoring floating population and controlling imported malaria (1980-2009), and the stage of comprehensive elimination (2010-2018), The epidemic and transmission of malaria were gradually controlled.The incidence of malaria dropped below 1% in 1958, below 1‰ in 1965, below 1/10,000 in 1986, and no local infections occurred in 2005-2018. The goal of eliminating malaria was reached in 2015. Conclusion Malaria has been basically eliminated in Meizhou City,but the epidemiological factors of malaria still exist and the sustained challenges of imported malaria remain.