Objective To investigate the epidemiological characteristics and regularity of hand foot and mouth disease (HFMD) by analyzing the report and monitoring data of HFMD. Methods Based on the surveillance data of HFMD in the Infectious Disease Reporting Information Management System, throat swab specimens of HFMD patients were collected, enterovirus nucleic acid was detected and typed.The epidemiological characteristics and pathogenic surveillance data of HFMD in Huaining County from 2014 to 2018 were analyzed. Results From 2014 to 2018, 2675 cases of HFMD were reported in Huaining County.The 5-year annual incidence rate was 88.61/100,000, the peak of the epidemic was mainly from April to June, and the level of reported morbidity in different townships was obviously different.There was significant difference in the average annual incidence between people under 5 years old and those over 5 years old.(χ²=6774.70,P<0.001).There was significant difference in the average annual incidence between males and females (χ²= 28.794, P<0.001).The positive rate of etiological detection of HFMD in 5 years was 62.24%.Other enterovirus infections were the most common (61.16%) among the positive samples. Conclusion HFMD has obvious seasonal and population characteristics in Huaining County.Prevention and control measures forscattered children and densely populated places should be strengthened.