Objective To understand the occurrence regularity of tsutsugamushi disease in Yiyuan County, reduce misdiagnosis of tsutsugamushi disease and improve the level of prevention and control. Methods Descriptive epidemiology was used to analyze the data of tsutsugamushi disease in Yiyuan County from 2014 to 2017. Results In Yiyuan County, 62.8% of tsutsugamushi patients were male and 37.2% were female,36-45 years old was the age group with high incidence of tsutsugamushi typhus, accounting for 41.0%. Most tsutsugamushi disease cases occurred in October, accounting for 45.5%. The main clinical manifestations were patients with fever symptoms,90.4% of patients had specific skin irritations or ulcers, 81.4% of patients showed lymphadenopathy. Conclusion The key to prevention and control of tsutsugamushi disease in Wuyuan County is to strengthen the health education of natural epidemic diseases in autumn, to strengthen the protection of wild activities of young and middle-aged people, and improve the differential diagnosis of tsutsugamushi by clinicians.