Objective To analyze the epidemiological characteristics and post-exposure disposal of the exposed population in the rabies clinics of a town in Dongguan City, so as to provide scientific basis for the prevention and control of rabies in this area. Methods Data were collected and analyzed according to the Monthly Report of Rabies Outpatient Exposure Surveillance in Guangdong Province (2011 edition). Results From 2014 to 2018, a town in Dongguan City reported 19 885 cases of rabies exposure. The number of rabies exposure increased in the past five years, with a maximum of 4774 cases in 2018. July-October was the peak period of exposure, accounting for 39.18% of the total number of exposure in five years. The ratio of male to female was 1.23∶1, and the population aged 15-44 (52.28% of the exposed population) was at high risk of rabies exposure. Most of the exposed sites were upper limbs (50.0%) and lower limbs (42.9%). Most of them were single exposure (88.55%), superficial exposure (84.03%) and secondary exposure (74.63%). Dog injuries accounted for 60.39%, wound treatment accounted for 82.82%, rabies vaccination accounted for 98.38%, rabies immune globulin injection rate of grade III exposures was 41.86%. The vaccination rates of rabies immunoglobulin in different occupations (χ²=1384.333,P< 0.001), educational level (χ²= 494.407,P< 0.001), household registration (χ²= 277.781,P<0.001) and gender (χ²=15.569,P< 0.001) were significantly different among the third-grade exposed persons. Comparisons show that the population with the highest vaccination rate was those who work in enterprises and institutions and their education background were junior college or above. No cases of rabies were reported by the surveillance system. Conclusion The exposure rate of rabies in a town in Dongguan City is relatively high. It is necessary to carry out extensive propaganda and education, continue to strengthen canine immunity, standardize the treatment of canine injuries, and promote legislation on rabies prevention and management, so as to create a civilized social atmosphere for raising dogs.