Objective To understand the epidemiological characteristics and incidence trend of five kinds of surveillance STDs in Huaibei City from 2014 to 2018, and to provide scientific basis for formulating prevention and control strategies. Methods Data of STD cases reported through the National Information System for Disease Prevention and Control in Huaibei City from 2014 to 2018 were collected, and the epidemiological characteristics were analyzed. Results From 2014 to 2018, 4 018 cases of five kinds of STDs were reported in Huaibei City. The top two diseases were syphilis and condyloma acuminatum, totaling 3 108 cases, accounting for 77.3% of the total reported cases.Recessive syphilis accounted for 68.4% of reported syphilis cases (1 196/1 748). The annual reported incidence showed an upward trend (χ²_trend=38.621,P<0.001). All the three districts and one county in Huaibei City had reported cases, of which Suixi County had the largest number of reported cases, accounting for 45.9%. Men accounted for 52.8% and women for 47.2%. The ratio of male to female was 1.12∶1, and the ratio of male was higher than that of female. Cases were reported in different age groups, of which the 20-year-old group had the largest number of cases, mainly concentrated in the 20-49 years old. Their occupations were mainly farmers, houseworkers and unemployed people, accounting for 69.4% of all reported cases. Conclusion The epidemic situation of venereal diseases in Huaibei City from 2014 to 2018 is on the rise, and the situation of prevention and control is not optimistic. The monitoring of syphilis and condyloma acuminatum cases should be strengthened, and targeted propaganda and health education should be carried out.