Objective To explore the correlation between risk factors of pregnant women and premature deliverybirth. Methods Data were collected from the National Free Prenatal Health Examination Project Information System and the follow-up registration form.Multivariate Poisson regression models wasere fitted with premature birth, spontaneous abortion and low birth weight as strain variables.Furthermore, Restricted Cubic Spline (RCS), which combines spline function with Poisson regression, was used to analyze the non-linear dose-response relationship between pre-pregnancy weight, women's age and preterm deliverybirth. Results The results of multivariate Poisson regression model showed that women's age, pre-pregnancy BMI before pregnancy, parity, number of births, pre-pregnancy mammary gland hyperplasia and pre-pregnancy leucorrhea cleanliness breast hyperplasia before pregnancy and cleanliness of leucorrhea before pregnancy were significantly correlated with the risk of premature deliverybirth.Restricted cubic spline model showed a U-shaped dose-response relationship between women's age and preterm deliverybirth, and the lowest incidence of preterm delivery birth was around 26 years old.There was a "S" dose-response relationship between pre-pregnancy BMI and the risk of premature bitthdelivery.When BMI was higher greater than 24, the risk of premature delivery birth began to increase gradually with the increase of BMI. Conclusion There is a non-linear dose-response relationship between women's age and , pre-pregnancy BMI and the risk of premature birth, which has important guiding significance for health education before pregnancy.and BMI before pregnancy is of great guiding significance for health education of eugenics and eugenics before pregnancy.
Key words
Eugenics /
Risk factors /
Dose-response relationship /
Cohort study
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 庞厚雯.育龄妇女免费孕前优生健康检查服务中综合干预的应用效果[J].中国卫生工程学,2017,16(4):476-477.
[2] 高秀红,傅雪君.孕前优生指导配合规范化孕期保健在高龄产妇中的应用及对妊娠结局的影响[J].中国妇幼保健,2018,33(3):539-542.
[3] 蒋芳,高劲松,钟逸锋,等.北京协和医院25年早产状况的调查[J].中国医学科学院学报,2016,38(5):528-533.
[4] 仲秀丽,丁亚囡,王佳琦,等.1989—2017年住院分娩4738例早产活产儿临床资料分析[J].南通大学学报(医学版),2018,38(6):467-469.
[5] Shi TL, Huang LJ, Xiong YQ,et al.The risk of herpes simplex virus and human cytomegalovirus infection during pregnancy upon adverse pregnancy outcomes: A meta-analysis[J].J Clin Virol,2018, 104: 48-55.
[6] Ahmadi A,Ramazanzadeh R,Sayehmiri K,et al.Association of Chlamydia trachomatis infections with preterm delivery; a systematic review and meta-analysis[J].BMC Pregnancy Childbirth,2018,18(1): 240.
[7] Roustaei Z, Vehviläinen-Julkunen K, Tuomainen TP,et al.The effect of advanced maternal age on maternal and neonatal outcomes of placenta previa: A register-based cohort study[J].Eur J Obstet Gynecol Reprod Biol,2018,227: 1-7.[8] Fuchs F, Monet B, Ducruet T,et al.Effect of maternal age on the risk of preterm birth:A large cohort study[J].PLoS One,2018,13(1):e0191002.
[9] Hegelund ER,Urhoj SK,Andersen AN,et al.Interpregnancy Interval and Risk of Adverse Pregnancy Outcomes: A Register-Based Study of 328,577 Pregnancies in Denmark 1994-2010[J].Matern Child Health J,2018,22(7):1008-1015.
[10] Zhang X,Xu Q,Yang Y,et al.Preconception Hb concentration and risk of preterm birth in over 2.7 million Chinese women aged 20-49 years: a population-based cohort study[J].Br J Nutr,2018,120(5):508-516.
[11] 张丹丹.孕前BMI及孕期增重速度与不良妊娠结局的关联分析[D].武汉:华中科技大学,2016.
[12] Desquilbet L,Mariotti F.Dose-response analyses using restricted cubic spline functions in public health research[J].Stat Med,2010,29(9):1037-57.
[13] Gregory M,Ulmer H,Pfeiffer KP,et al.A set of SAS macros for calculating and displaying adjusted odds ratios (with confidence intervals) for continuous covariates in logistic B-spline regression models[J].Comput Methods Programs Biomed,2008,92(1):109-14.
[14] Sung SJ,Lee SM,Kim S,et al.The Risk of Spontaneous Preterm Birth according to Maternal Pre-pregnancy Body Mass Index in Twin Gestations[J].J Korean Med Sci,2018, 33(13): e103.
[15] 王璇,陈廷美,于德纯,等.经产妇孕期增重及妊娠结局的调查分析[J].现代妇产科进展,2019,28(1):45-47.
PDF(903 KB)
