Objective To understand the Characteristic and trends of notifiable infectious diseases in Zhaoqing City, Guangdong Province, from 2009 to 2018, and to provide scientific basis for the formulation of control measures. Methods Descriptive epidemiological methods were used to collect and analyze the epidemiological data of notifiable infectious diseases in Zhaoqing from 2009 to 2018. Results From 2009 to 2018, there were 350 485 cases of 28 kinds of notifiable infectious diseases in Zhaoqing, with an average annual incidence of 88.09/100,000.There were no reports of Class A infectious diseases;20 kinds of infectious diseases of Class B were reported,with a total of 128 755 cases, the average annual incidence was 323.31/100,000;8 kinds of Class C infectious diseases were reported, totaling 221 730 cases, with an average annual incidence of 556.78/100,000.The main infectious diseases were hand, foot and mouth disease (accounting for 37.88%), viral hepatitis (accounting for 21.45%), other infectious diarrhea diseases (accounting for 16.83%) and tuberculosis (accounting for 9.45%).Hot infectious diseases such as dengue fever and new infectious disease H7N9 avian influenza also occurred. Conclusion The prevention and control of notifiable infectious diseases in Zhaoqing should focus on hand, foot and mouth disease, viral hepatitis (especially hepatitis B), other infectious diarrhea diseases, tuberculosis, and AIDS.At the same time, the emergence of new infectious diseases should be noticed, epidemic surveillance should be strengthened, and timely preventive and control measures should be taken.