Objective To analyze the epidemiological trend of hand,foot and mouth disease (HFMD) in Bengbu City from 2009 to 2018,and to explore the influence of meteorological factors on HFMD. Methods Descriptive epidemiological method was used to analyze the surveillance results of HFMD and etiology in "Infectious Disease Reporting Information Management System" in Bengbu City.Spearson correlation coefficient was used to describe the relationships between monthly incidence of HFMD and monthly mean rainfall,monthly mean sunshine hours,monthly mean wind speed and monthly mean temperature. Results A total of 77 148 cases of HFMD were reported in Bengbu from 2009 to 2018,with an average annual reported incidence of 231.91/100,000.From 2009 to 2012,the number of reported cases increased year by year.After 2013,there was a high incidence every other year.The incidence rate was higher in even years.The peak incidence was in April-June,the highest was in May (43.40/100,000) and the lowest was in January (7.58/100,000).Children under 5 years old and scattered children were at high risk with a male-female ratio of 1.63:1.Pathogenic surveillance samples were collected from 4293 cases and 2120 cases were positive,including 901 cases of EV71,500 cases of Cox-A16 and 719 Cases of other enteroviruses.The incidence of HFMD tended to peak when the temperature was 16-25℃.When the temperature was higher than 26℃,the incidence decreased,and the wind speed was positively correlated with the incidence.The linear regression equation was the monthly incidence of HFMD=-11.244+0.704* monthly mean temperature+8.184* monthly mean wind speed. Conclusion Bengbu City is a high incidence area of HFMD,which is periodically prevalent.Its seasonal and population distribution characteristics are obvious,and it is closely related to temperature and wind speed.